Dr. Antonio Condino-Neto

@article{pmid38175961,

title = {Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children},

author = {Paul Bastard and Adrian Gervais and Maki Taniguchi and Liisa Saare and Karita Särekannu and Tom Le Voyer and Quentin Philippot and Jérémie Rosain and Lucy Bizien and Takaki Asano and Marina Garcia-Prat and Alba Parra-Martínez and Mélanie Migaud and Miyuki Tsumura and Francesca Conti and Alexandre Belot and Jacques G Rivière and Tomohiro Morio and Junko Tanaka and Etienne Javouhey and Filomeen Haerynck and Sotirija Duvlis and Tayfun Ozcelik and Sevgi Keles and Yacine Tandjaoui-Lambiotte and Simon Escoda and Maya Husain and Qiang Pan-Hammarström and Lennart Hammarström and Gloria Ahlijah and Anthony Abi Haidar and Camille Soudee and Vincent Arseguel and Hassan Abolhassani and Sabina Sahanic and Ivan Tancevski and Yoko Nukui and Seiichi Hayakawa and George P Chrousos and Athanasios Michos and Elizabeth-Barbara Tatsi and Filippos Filippatos and Agusti Rodriguez-Palmero and Jesus Troya and Imran Tipu and Isabelle Meyts and Lucie Roussel and Sisse Rye Ostrowski and Laire Schidlowski and Carolina Prando and Antonio Condino-Neto and Nathalie Cheikh and Ahmed A Bousfiha and Jalila El Bakkouri and and and and Pärt Peterson and Aurora Pujol and Romain Lévy and Pierre Quartier and Donald C Vinh and Bertrand Boisson and Vivien Béziat and Shen-Ying Zhang and Alessandro Borghesi and Andrea Pession and Evangelos Andreakos and Nico Marr and Alexios-Fotios A Mentis and Trine H Mogensen and Carlos Rodríguez-Gallego and Pere Soler-Palacin and Roger Colobran and Vallo Tillmann and Bénédicte Neven and Sophie Trouillet-Assant and Petter Brodin and Laurent Abel and Emmanuelle Jouanguy and Qian Zhang and Federico Martinón-Torres and Antonio Salas and Alberto Gómez-Carballa and Luis I Gonzalez-Granado and Kai Kisand and Satoshi Okada and Anne Puel and Aurélie Cobat and Jean-Laurent Casanova},

doi = {10.1084/jem.20231353},

issn = {1540-9538},

year  = {2024},

date = {2024-02-01},

urldate = {2024-02-01},

journal = {J Exp Med},

volume = {221},

number = {2},

abstract = {We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.},

keywords = {COVID-19, pneumonia},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39507534b,

title = {Calculated globulin can be used as a screening test for antibody deficiency in children and adolescents},

author = {Cristina Frias Sartorelli de Toledo Piza and Carolina Sanchez Aranda and Dirceu Solé and Stephen Jolles and Antonio Condino-Neto},

doi = {10.3389/fimmu.2024.1495564},

issn = {1664-3224},

year  = {2024},

date = {2024-01-01},

journal = {Front Immunol},

volume = {15},

pages = {1495564},

abstract = {PURPOSE: Calculated globulin (CG, total protein minus albumin levels) correlate well with IgG levels and has been proposed as a suitable screening method for individuals with primary antibody deficiencies (PADs). We aimed to show the correlation of CG with IgG levels in children and adolescents, utilizing a common method for albumin measurement, bromocresol green.nnMETHODS: Individuals from two Allergy and Immunology clinics were invited to participate. Inclusion criteria were age < 18, stable conditions, and signed informed consent. We included 1084 individuals. Immunoglobulin G values were determined by immunoturbidimetry; the colorimetric bromocresol green method and the Architect Biuret method were utilized for the albumin and total protein (TP) measurements, respectively.nnRESULTS: A total of 1084 individuals were included in the analysis and divided into 4 age groups (0 to <1 year, 1 to <4 years, 4 to <10 years, and 10 to <18 years). For all patients, the mean age was 6.1 (± 5) years old, the mean IgG was 9.4 (± 4.7) g/L, and CG was 23.7 (± 5.9) g/L. The most frequent diagnosis were respiratory allergies, followed by inborn errors of immunity. IgG and CG varied according to age group. Cutoff values for hypogammaglobulinemia varied from 13.8 g/L in children < 1 year to 23.1 g/L in children and adolescents aged 10 to <18 years. CG sensitivity varied from 70.9% in children aged 1 to <4 years old to 95.8% in children 4 to <10. Specificity ranged from 87.5% in children 4 to <10 years old to 100% in children and adolescents aged 10 to <18 years.nnCONCLUSION: CG is a suitable screening test for hypogammaglobulinemia in children less than 18 years of age.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid39507534,

title = {Calculated globulin can be used as a screening test for antibody deficiency in children and adolescents},

author = {Cristina Frias Sartorelli de Toledo Piza and Carolina Sanchez Aranda and Dirceu Solé and Stephen Jolles and Antonio Condino-Neto},

doi = {10.3389/fimmu.2024.1495564},

issn = {1664-3224},

year  = {2024},

date = {2024-01-01},

urldate = {2024-01-01},

journal = {Front Immunol},

volume = {15},

pages = {1495564},

abstract = {PURPOSE: Calculated globulin (CG, total protein minus albumin levels) correlate well with IgG levels and has been proposed as a suitable screening method for individuals with primary antibody deficiencies (PADs). We aimed to show the correlation of CG with IgG levels in children and adolescents, utilizing a common method for albumin measurement, bromocresol green.nnMETHODS: Individuals from two Allergy and Immunology clinics were invited to participate. Inclusion criteria were age < 18, stable conditions, and signed informed consent. We included 1084 individuals. Immunoglobulin G values were determined by immunoturbidimetry; the colorimetric bromocresol green method and the Architect Biuret method were utilized for the albumin and total protein (TP) measurements, respectively.nnRESULTS: A total of 1084 individuals were included in the analysis and divided into 4 age groups (0 to <1 year, 1 to <4 years, 4 to <10 years, and 10 to <18 years). For all patients, the mean age was 6.1 (± 5) years old, the mean IgG was 9.4 (± 4.7) g/L, and CG was 23.7 (± 5.9) g/L. The most frequent diagnosis were respiratory allergies, followed by inborn errors of immunity. IgG and CG varied according to age group. Cutoff values for hypogammaglobulinemia varied from 13.8 g/L in children < 1 year to 23.1 g/L in children and adolescents aged 10 to <18 years. CG sensitivity varied from 70.9% in children aged 1 to <4 years old to 95.8% in children 4 to <10. Specificity ranged from 87.5% in children 4 to <10 years old to 100% in children and adolescents aged 10 to <18 years.nnCONCLUSION: CG is a suitable screening test for hypogammaglobulinemia in children less than 18 years of age.},

keywords = {imunidade},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37505322b,

title = {Screening for Antibody Deficiencies in Adults by Serum Electrophoresis and Calculated Globin},

author = {Cristina Frias Sartorelli de Toledo Piza and Carolina Sanchez Aranda and Dirceu Solé and Stephen Jolles and Antonio Condino-Neto},

doi = {10.1007/s10875-023-01536-1},

issn = {1573-2592},

year  = {2023},

date = {2023-11-01},

journal = {J Clin Immunol},

volume = {43},

number = {8},

pages = {1873--1880},

abstract = {PURPOSE: This study aimed to investigate the correlation between calculated globulin (CG, total protein level minus albumin level) and the gamma globulin fraction (Gamma), obtained from serum protein electrophoresis with serum IgG levels in adults (≥ 18 years).nnMETHODS: Using linear regression models, analyses of CG and Gamma levels correlation with IgG levels in adults were performed. Receiver-operator curves were created to determine cutoff values and the respective sensitivity and specificity measures.nnRESULTS: A total of 886 samples were analyzed. CG and Gamma were positively and statistically correlated with IgG levels (r = 0.4628 for CG, and = 0.7941 for Gamma, p < 0.0001 for both analyses). For the detection of hypogammaglobulinemia, i.e., IgG level below the reference value (6 g/L), a CG cutoff value of 24 g/L showed a sensitivity of 86.2% (95% CI 69.4-94.5) and a specificity of 92% (90.0-93.6). A Gamma cutoff value of 7.15 g/L yielded a sensitivity of 100% (88.3-100) and a specificity of 96.8 (95.3-97.8).nnCONCLUSION: Both CG and Gamma levels determined by protein electrophoresis analysis may be used to screen for antibody deficiencies in adults, enabling earlier diagnosis of antibody deficiencies in a routine clinical setting.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37505322,

title = {Screening for Antibody Deficiencies in Adults by Serum Electrophoresis and Calculated Globin},

author = {Cristina Frias Sartorelli de Toledo Piza and Carolina Sanchez Aranda and Dirceu Solé and Stephen Jolles and Antonio Condino-Neto},

doi = {10.1007/s10875-023-01536-1},

issn = {1573-2592},

year  = {2023},

date = {2023-11-01},

urldate = {2023-11-01},

journal = {J Clin Immunol},

volume = {43},

number = {8},

pages = {1873--1880},

abstract = {PURPOSE: This study aimed to investigate the correlation between calculated globulin (CG, total protein level minus albumin level) and the gamma globulin fraction (Gamma), obtained from serum protein electrophoresis with serum IgG levels in adults (≥ 18 years).nnMETHODS: Using linear regression models, analyses of CG and Gamma levels correlation with IgG levels in adults were performed. Receiver-operator curves were created to determine cutoff values and the respective sensitivity and specificity measures.nnRESULTS: A total of 886 samples were analyzed. CG and Gamma were positively and statistically correlated with IgG levels (r = 0.4628 for CG, and = 0.7941 for Gamma, p < 0.0001 for both analyses). For the detection of hypogammaglobulinemia, i.e., IgG level below the reference value (6 g/L), a CG cutoff value of 24 g/L showed a sensitivity of 86.2% (95% CI 69.4-94.5) and a specificity of 92% (90.0-93.6). A Gamma cutoff value of 7.15 g/L yielded a sensitivity of 100% (88.3-100) and a specificity of 96.8 (95.3-97.8).nnCONCLUSION: Both CG and Gamma levels determined by protein electrophoresis analysis may be used to screen for antibody deficiencies in adults, enabling earlier diagnosis of antibody deficiencies in a routine clinical setting.},

keywords = {imunidade},

pubstate = {published},

tppubtype = {article}

}